Recipientofthe2007GoldenGlobeAwardforBestDramaTelevisionSeriesandmultipleEmmynominations,includingOutstandingDramaSeriesforthepasttwoyears,"Grey'sAnatomy"returnstotheABCTelevisionNetworkforitsfifthseason. Is"happilyeverafter"possibleforMeredithGreyandDerek"McDreamy"Shepherd?WithMeredithexperiencingabreakthroughintherapy-therealizationthatsheandDerekcanbeextraordinarytogether,ratherthanordinaryapart--sheandDereknowfacethehighsandlowsofbeingacommittedcouple. ContinuingtheirfirstyearasresidentsatSeattleGraceHospital,Meredith,CristinaYang,IzzieStevensandAlexKarevhaveinternsoftheirowntomentor,includingMeredith'shalf-sister,LexieGrey.LexiehasbecomearoommateandconfidantetoGeorgeO'Malley,who,afterdivorcewithCallie,abreakupwithIzzie,andlearningthathefailedhisresidencytestbyonlyonepoint,isstrivingtogetbothhisprofessionalandpersonallifebackontrack. AfterattendingtohisgirlfriendRebecca'smentalillnessonhisown,andrevealingthathehadgonethroughthiswithhisownmother,AlexfindssolaceinIzzie'sarms.Alexmustcontinuethroughthisdifficulttime,whetherornotIzzieremainsbyhisside. Cristina,havingfinallywonoutoverhertough-as-nailsmentor,Erica,isbackontrackasasurgeon-butisthereachancefornewloveinherlifeaswell? WiththeencouragementofMark"McSteamy"Sloan,Dr.CallieTorreshastakenachanceonlovewithcardiothoracicsurgeon,EricaHahn;now,sheandEricamustfigureoutwhathappensafterthefirstkiss. Overseeingtheresidentsistheno-nonsenseChiefResident,MirandaBailey.Facingmaritaltroublesandthedifficultyofbalancingherworkandpersonallife,BaileyhashandedherresponsibilitiesasheadofthefreeclinicovertoIzzie.AlsostrivingforbalanceisChiefofSurgery,RichardWebber,whohasreunitedwithhisestrangedwife,Adele. ThedoctorsofSeattleGraceHospitaldealwithlife-or-deathconsequencesonadailybasis-it'sinoneanotherthattheyfindcomfort,friendshipandlove.Togetherthey'rediscoveringthatneithermedicinenorrelationshipscanbedefinedinblackandwhite.Reallifeonlycomesinshadesofgrey. "Grey'sAnatomy"starsEllenPompeoasMeredithGrey,PatrickDempseyasDerekShepherd,SandraOhasCristinaYang,KatherineHeiglasIsobel"Izzie"Stevens,JustinChambersasAlexKarev,T.R.KnightasGeorgeO'Malley,ChandraWilsonasMirandaBailey,JamesPickens,Jr.asRichardWebber,SaraRamirezasCallieTorres,EricDaneasMarkSloan,ChylerLeighasLexieGrey,andBrookeSmithasEricaHahn.